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Sharma, M.
- Hemato-Biochemical Alterations Mediated by Carbendazim Exposure and Protective Effect of Quercetin in Male Rats
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1 Department of Veterinary Pharmacology and Toxicology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana − 141004, Punjab, IN
2 Department of Veterinary Physiology and Biochemistry, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana − 141004, Punjab, IN
1 Department of Veterinary Pharmacology and Toxicology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana − 141004, Punjab, IN
2 Department of Veterinary Physiology and Biochemistry, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana − 141004, Punjab, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 25, No 1 (2018), Pagination: 7-18Abstract
The main objective of study was to investigate the effect of Carbendazim (CBZ) a most popular agriculture fungicide on hemato-biochemical alterations in male rats and possible ameliorative effect of quercetin. Sprague Dawley male rats were administered CBZ @100, 200 and 400 mg/kg body weight, PO and quercetin (25mg/kg body weight, PO) alone and concomitant in corn oil for the period of 28 days. At the end of exposure period, blood was collected and hemato-biochemical parameters were evaluated in blood and plasma samples. Sub-acute exposure of carbendazim resulted in non-significant decrease (p > 0.05) in haemoglobin, PVC and TEC and increase in MCV, MCH and platelets count in CBZ treated groups. Moreover, administration of CBZ significantly increased (p < 0.05) the plasma ALT, AST, ALP, cholesterol and triglyceride while, significantly decreased (p < 0.05) the plasma protein and globulin level was noticed. Non-significant change in calcium, chloride and phosphorous was observed in CBZ alone treated groups. However, quercetin supplementation concomitant in CBZ treated animals prevented and restored the alterations caused by exposure of CBZ. This study concluded that quercetin has ability to ameliorate the toxic effect caused by CBZ on hemato-biochemical biomarkers in living beings.Keywords
Carbendazim, Haemato-Biochemical, Quercetin, Rats.
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- Toxicological Sequelae of Pesticide Combinations Exposure in Buffalo Mesenchymal Stem Cells under In Vitro
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Authors
Affiliations
1 Department of Veterinary Pharmacology and Toxicology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana – 141004, Punjab, IN
2 Department of Veterinary Physiology and Biochemistry, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana – 141004, Punjab, IN
3 Department of Veterinary Surgery and Radiology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana – 141004, Punjab, IN
1 Department of Veterinary Pharmacology and Toxicology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana – 141004, Punjab, IN
2 Department of Veterinary Physiology and Biochemistry, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana – 141004, Punjab, IN
3 Department of Veterinary Surgery and Radiology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana – 141004, Punjab, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 29, No 1 (2022), Pagination: 1-14Abstract
The presence of one or more pesticides in a variety of mediums is responsible for their indirect toxicological events leading to cell senescence. In the present investigation, the endeavor was made to see the effect of pesticides Car-Benda-Zim (CBZ) and IMIdacloprid (IMI) alone and in combination with bone marrow-derived Mesenchymal Stem Cells (bMSCs) of buffalo origin. Isolated and cultured bMSCs were exposed to CBZ and IMI alone and in combinations at lower doses. Cells were observed for alterations in cell morphology, oxidative stress, mitochondrial damage and cellular senescence. bMSCs characterized for stem cell surface markers and found to be positive for AP, CD73 and OCT4. bMSCs exposed to IC25, IC12.5 and IC6.25 CBZ and IMI alone and combinations of IC12.5 and IC6.25 of CBZ and IMI. Results revealed significant reduction (p≤0.05) in cell viability noticed on microscopic examination along with loss of normal cell morphology and increased in Reactive Oxygen Species (ROS) positive cells, cells with loss of ΔΨm and number of senescent cells in CBZ and IMI treated groups. Lower dose combination groups showed elevated effects when compared with higher dose alone treated groups and control groups. Present findings suggest that CBZ and IMI induced cytotoxicity in bMSCs mediated via ROS production, altered ΔΨm leading to the cell damage and predisposing senescence process. Moreover, the co-existence of CBZ and IMI in a medium has a considerably more toxic effect than their individual effect.Keywords
Carbendazim, Imidacloprid, Stem Cells, Mitochondrial Transmemberane Potential, Reactive (ROS), SenescenceReferences
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